Themes and variations in ER/SR calcium release channels: structure and function.

نویسندگان

  • Peter B Stathopulos
  • Min-duk Seo
  • Masahiro Enomoto
  • Fernando J Amador
  • Noboru Ishiyama
  • Mitsuhiko Ikura
چکیده

Calcium (Ca(2+)) release from reticular stores is a vital regulatory signal in eukaryotes. Recent structural data on large NH(2)-terminal regions of IP(3)Rs and RyRs and their tetrameric arrangement in the full-length context reveal striking mechanistic similarities in Ca(2+) release channel function. A common ancestor found in unicellular genomes underscores the fundamentality of these elements to Ca(2+) release channels.

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عنوان ژورنال:
  • Physiology

دوره 27 6  شماره 

صفحات  -

تاریخ انتشار 2012